Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a joint strike targeting an underground arms cache in Syrian territory used by the Daesh militant organization, according to the UK's MoD.
The facility, identified by surveillance, was thought to be housing weapons and explosive materials, the statement said, and was positioned in mountains just north of Palmyra in Syria's central region.
"Our aircraft used precision-guided Paveway IV munitions to target a several approach shafts providing entry to the facility... preliminary assessments indicate the strike was effective," the ministry announced.
There was no sign of any civilian impact in the strike late on Saturday and every plane involved returned safely, the ministry further stated.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
The Islamic State group - alternatively referred to as ISIS - imposed militant control over parts of Syria and Iraq prior to its 2019 collapse.
"This operation shows the UK's leading role, and determination to stand shoulder to shoulder with our allies, to eradicate any re-emergence of IS and their violent and radical beliefs in the region," Britain's Defence Chief John Healey stated.
UK warplanes have carried out overwatch operations over Syria to "prevent any efforts to regroup" of the group after its defeat at the battle of Baghuz in 2019, the ministry said.
"I want to thank all the members of the UK armed forces involved in this mission for their skill and their courage," the Defence Secretary commented. "Including them were a great many British troops stationed over Christmas and New Year. This mission, to remove terrorist threats who threaten our way of life, highlights how British military are ready to step up, throughout the year, protecting the UK within its borders and strong abroad."
During December, the US military carried out what it described as a "major assault" targeting IS targets in Syria, following an attack resulted in the deaths of two American soldiers and a civilian interpreter in Palmyra.
The United Nations says Islamic State still boasts an estimated 5,000 to 7,000 fighters in both countries.